JAMA Psychiatry Study on Ketamine Use

Last Updated: 2023 / March

What we found

• A meta-analysis published in JAMA Psychiatry in May 2019 found that ketamine demonstrated a significant effect in reducing depressive symptoms in patients with treatment-resistant depression, with effects observed within 24 hours of treatment.

The Lancet Psychiatry Study on Ketamine Use

Last Updated: 2023 / March

What we found

• A randomized controlled trial published in The Lancet Psychiatry in June 2019 compared intranasal esketamine to placebo in patients with treatment-resistant depression. The study found that esketamine produced a significant and rapid reduction in depressive symptoms, with effects observed within 24 hours of treatment.

The British Journal of Psychiatry Study on Ketamine Use

Last Updated: 2023 / March

What we found

• A systematic review and meta-analysis published in 2018 looked at 28 studies involving a total of 1,023 participants and found that ketamine was an effective treatment for depressive symptoms in individuals with major depressive disorder and bipolar disorder. The study also found that the antidepressant effects of ketamine were rapid, with improvement seen within hours to days.